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O. Winfrey What I Know For Sure Books non-invasive system that it returnsAfter film critic Gene Siskel asked her, 'What do you know for sure?' Oprah Winfrey began writing the 'What I Know For Sure' column in O, The Oprah Magazine. Saying that the question offered her a way to take 'stock of her life', Oprah has penned one column a month over the last fourteen years, years in which she retired The Oprah Winfrey Show (the highest rated program of its kind in history), launched her own television network, became America's